Nintendo UK's marketing director and assistant general manager will leave the company on February 24.
"Dawn has been a valuable member of the Nintendo UK Senior Management team and over her 10 years with the company has contributed greatly to our success through her leadership of the award winning NUK Marketing Team" said general manager David Yarnton.
"We would like to thank Dawn for everything that she has done and achieved during her time at Nintendo and we wish her all the best in the future."
During her 10 years with the company, and was instrumental in the launches and management of products like the Wii, Nintendo 3DS and Wii Fit.
Paine has made no announcement about her next role.