EGX Rezzed will not be held this year.
The event was previously due to be hosted at London's Tobacco Dock in March, but was then postponed to July due to the initial impact of the coronavirus.
Given the ongoing effect of the pandemic, organisers Gamer Network and Reed Pop have decided to cancel the event and focus instead on the 2021 iteration.
In a statement, the company said: "The effects, actual and projected, of Coronavirus are becoming evident across all aspects of our lives here in the UK and across the world, with many of our exhibitors and creators facing travel restrictions and quarantine measures.
"After extensive discussions with all the relevant public health, local and national authorities, and with our Rezzed partners, we have taken the decision not to go ahead with this year's event.
"We thank everyone who has prepared to deliver what promised to be a fantastic event over the past year, showcasing the best of indie gaming to the incredible Rezzed community."
The show's larger companion EGX is currently scheduled to run from September 17 to 20.
All Rezzed tickets have automatically been upgraded to allow entry to EGX, but full refunds are available to those how prefer. Simply email email@example.com with your order number.