Mass Effect 2 has shipped two million units since its release one week ago, according to internal EA figures.
The publisher called the game the first blockbuster of 2010, pointing out that it has earned an average review score of 96 on Xbox 360 on Metacritic, which include 40 'perfect' scores.
"Mass Effect 2 is poised to be one of the biggest games of 2010. We could not be more proud of the game's universal acclaim and early commercial success," said Dr Ray Muzyka, co-founder of BioWare and group general manager of the RPG/MMO group of EA.
The game was released in North America on January 26 and across Europe on the 29th.
At the start of the year, GamesIndustry.biz Network members voted the game as their most anticipated for 2010.