Estimated day one sales of Modern Warfare 3, based on Charttrack and retailer figures, stand at 6.5 million units in the US and UK alone, raising $400 million in revenues.
The numbers make it the biggest entertainment launch of all time, beating the previous record held by Call of Duty: Black Ops which had an estimated day one revenue total in the territories of $360 million.
It's the third year in a row in which the series has broken all time entertainment sales records.
"We believe the launch of Call of Duty: Modern Warfare 3 is the biggest entertainment launch of all time in any medium, and we achieved this record with sales from only two territories," said Bobby Kotick.
"Other than Call of Duty, there has never been another entertainment franchise that has set opening day records three years in a row. Life-to-date sales for the Call of Duty franchise exceed worldwide theatrical box office for 'Star Wars' and 'Lord of the Rings,' two of the most successful entertainment franchises of all time."
Alongside the announcement, Activision revealed that it had donated a further $3 million to the Call of Duty Endowment which Kotick set up in 2009, bringing the total to $5 million. The fund exists to provide training and employment to veterans of the US armed forces.